Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 26 Researches
6.7
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 1 Chewable Tablet
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
25 mcg (1,000 IU)
125%
Top Medical Research Studies
8
We explored the potential benefits of vitamin D3 supplementation in alleviating knee pain associated with osteoarthritis (OA). In this open-label clinical trial, we assessed the effects of daily doses of 4000 IU vitamin D3 over three months in 80 patients suffering from knee OA.
Our findings revealed notable improvements in pain levels and overall physical function. The patients showed significant reductions in pain scores measured by the Visual Analog Scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) subscores after the treatment period. Remarkably, 86.7% of those treated responded positively to the therapy.
Interestingly, we observed changes in systemic cytokine levels: while some pro-inflammatory markers increased, others, including TNF-α and IL-17, showed significant reductions. This suggests that vitamin D3 not only helps with pain relief but also may influence inflammatory processes in the body.
Overall, our results indicate that vitamin D3 supplementation could be a promising therapeutic option for managing symptoms of knee OA. Nonetheless, future research should further investigate the role of specific inflammatory mediators, like IL-33, in the progression of knee osteoarthritis.
Our findings revealed notable improvements in pain levels and overall physical function. The patients showed significant reductions in pain scores measured by the Visual Analog Scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) subscores after the treatment period. Remarkably, 86.7% of those treated responded positively to the therapy.
Interestingly, we observed changes in systemic cytokine levels: while some pro-inflammatory markers increased, others, including TNF-α and IL-17, showed significant reductions. This suggests that vitamin D3 not only helps with pain relief but also may influence inflammatory processes in the body.
Overall, our results indicate that vitamin D3 supplementation could be a promising therapeutic option for managing symptoms of knee OA. Nonetheless, future research should further investigate the role of specific inflammatory mediators, like IL-33, in the progression of knee osteoarthritis.
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1
We conducted a thorough investigation into the effects of vitamin D3 supplementation on knee pain and cartilage volume in people suffering from knee osteoarthritis, particularly those with low vitamin D levels. This study took place in Tasmania and Victoria, Australia, and was designed as a multicenter, randomized, double-blind, placebo-controlled clinical trial.
Over a span of two years, we divided participants into two groups: one received a monthly dose of oral vitamin D3 (50,000 IU), while the other group received a placebo. Our main focus was to evaluate any changes in tibial cartilage volume, measured through MRI, as well as the participants' knee pain levels as indicated by the Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score.
The results showed that, compared to the placebo group, those who received vitamin D3 experienced no significant differences in either tibial cartilage volume or reported knee pain over the two years. This indicates that vitamin D3 supplementation does not provide meaningful benefits for reducing tibial cartilage loss or improving knee pain in patients with symptomatic knee osteoarthritis.
Over a span of two years, we divided participants into two groups: one received a monthly dose of oral vitamin D3 (50,000 IU), while the other group received a placebo. Our main focus was to evaluate any changes in tibial cartilage volume, measured through MRI, as well as the participants' knee pain levels as indicated by the Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score.
The results showed that, compared to the placebo group, those who received vitamin D3 experienced no significant differences in either tibial cartilage volume or reported knee pain over the two years. This indicates that vitamin D3 supplementation does not provide meaningful benefits for reducing tibial cartilage loss or improving knee pain in patients with symptomatic knee osteoarthritis.
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1
Vitamin D3 ineffective for knee pain
We conducted a thorough investigation into whether vitamin D3 supplementation could alleviate knee pain in individuals with osteoarthritis. Our study involved 146 participants, all experiencing symptomatic knee osteoarthritis. They were either given a placebo or oral doses of vitamin D3, specifically aimed at achieving serum levels greater than 36 ng/mL over two years.
The main focus was on evaluating changes in knee pain and cartilage loss, utilizing the Western Ontario and McMaster Universities (WOMAC) pain scale for symptoms and magnetic resonance imaging for cartilage assessment. Unfortunately, our findings revealed that vitamin D supplementation did not lead to any significant reduction in knee pain or cartilage loss when compared to the placebo.
While we were hopeful that vitamin D3 might provide some relief, the results clearly indicated that this approach did not yield the desired effects in patients suffering from knee osteoarthritis. This outcome is crucial as it helps to shape future treatment approaches for this common condition.
The main focus was on evaluating changes in knee pain and cartilage loss, utilizing the Western Ontario and McMaster Universities (WOMAC) pain scale for symptoms and magnetic resonance imaging for cartilage assessment. Unfortunately, our findings revealed that vitamin D supplementation did not lead to any significant reduction in knee pain or cartilage loss when compared to the placebo.
While we were hopeful that vitamin D3 might provide some relief, the results clearly indicated that this approach did not yield the desired effects in patients suffering from knee osteoarthritis. This outcome is crucial as it helps to shape future treatment approaches for this common condition.
Read More
Most Useful Reviews
9
Reduced knee pain
The most important thing is that my joints have stopped crunching and they hurt less. After getting tested, I discovered there was no underlying issue for my sensations. Now, after nearly three months of taking the dietary supplement, I’m delighted to find that I hardly feel any pain. My shoulder still aches, but my knee pain and discomfort in my fingers have significantly decreased.
Read More
7.5
Less knee pain
One of the best! This vitamin D is ideal for the whole family. My children enjoy taking it, and so do the adults. We take it consistently from September to May, as it’s essential in St. Petersburg. The dosage is perfect for our region, and I’ve noticed that my pain, including knee pain, has significantly lessened. I highly recommend it!
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 26 Researches
6.7
- All Researches
9
We focused on the effects of vitamin D (VITD) in reducing knee pain linked to osteoarthritis (OA) using a study conducted on Wistar rats. The rats were induced with OA through a combination of surgical methods known as ACLT (anterior cruciate ligament transection) along with medial meniscectomy. This allowed us to closely observe the direct impact of VITD on pain levels and cartilage health.
Our investigations revealed that VITD not only alleviated pain but also minimized cartilage destruction. We measured pain severity through various tests, examined knee structure through histopathological studies, and analyzed different biological markers including inflammatory cytokines and matrix metalloproteinases (MMPs), which are linked to cartilage degradation.
The results were quite promising. Not only did VITD show a significant reduction in pain, but it also decreased inflammation and the destruction of chondrocytes, or cartilage cells. These benefits appear to stem from VITD's ability to lower the expression of MMPs, which are known contributors to cartilage breakdown in OA.
Overall, our findings strongly suggest that adding vitamin D to treatment regimens could be beneficial for those suffering from knee pain related to osteoarthritis, making it a potential ally in managing this common joint condition.
Our investigations revealed that VITD not only alleviated pain but also minimized cartilage destruction. We measured pain severity through various tests, examined knee structure through histopathological studies, and analyzed different biological markers including inflammatory cytokines and matrix metalloproteinases (MMPs), which are linked to cartilage degradation.
The results were quite promising. Not only did VITD show a significant reduction in pain, but it also decreased inflammation and the destruction of chondrocytes, or cartilage cells. These benefits appear to stem from VITD's ability to lower the expression of MMPs, which are known contributors to cartilage breakdown in OA.
Overall, our findings strongly suggest that adding vitamin D to treatment regimens could be beneficial for those suffering from knee pain related to osteoarthritis, making it a potential ally in managing this common joint condition.
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9
We explored the effects of vitamin D (D3) on knee pain recovery after total knee arthroplasty (TKA). In our study, we enrolled 60 patients and categorized them into three groups based on their vitamin D levels. Some patients had sufficient vitamin D, while others were either given large doses of oral or intramuscular supplementation if they were found to be insufficient.
Our findings revealed that patients with insufficient vitamin D experienced significant improvements in their knee function after receiving large oral doses. In fact, those who received oral supplements showed recovery comparable to patients who already had sufficient vitamin D. Conversely, while intramuscular supplementation did increase vitamin D levels, it was less effective compared to the oral method and only showed noticeable improvement by the two-week mark.
Interestingly, we also noted that about 25% of patients who initially had sufficient vitamin D levels became insufficient within the first two weeks post-surgery. This indicates that even those with adequate levels may need to consider supplementation after undergoing TKA to maintain optimal recovery.
In summary, our study suggests that quickly addressing vitamin D deficiency with oral supplementation can play a crucial role in enhancing recovery and reducing knee pain following TKA.
Our findings revealed that patients with insufficient vitamin D experienced significant improvements in their knee function after receiving large oral doses. In fact, those who received oral supplements showed recovery comparable to patients who already had sufficient vitamin D. Conversely, while intramuscular supplementation did increase vitamin D levels, it was less effective compared to the oral method and only showed noticeable improvement by the two-week mark.
Interestingly, we also noted that about 25% of patients who initially had sufficient vitamin D levels became insufficient within the first two weeks post-surgery. This indicates that even those with adequate levels may need to consider supplementation after undergoing TKA to maintain optimal recovery.
In summary, our study suggests that quickly addressing vitamin D deficiency with oral supplementation can play a crucial role in enhancing recovery and reducing knee pain following TKA.
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9
We aimed to understand how vitamin D3 supplementation influences knee pain and muscle strength in individuals suffering from knee osteoarthritis (KOA). The study involved 67 patients over the age of 30, all experiencing knee pain for at least a month and showing signs of vitamin D deficiency.
Participants received a weekly dose of 50,000 IU of oral cholecalciferol (vitamin D3) for a span of two months. By the end of the treatment, nearly all participants had sufficient levels of vitamin D. Significant improvements were observed; serum vitamin D levels rose, quadriceps muscle strength increased, and knee pain decreased for the majority of participants.
Specifically, the pain reduction was measurable through standard pain assessment methods. The findings suggest a clear link between correcting vitamin D deficiency and improvements in both muscle strength and pain levels for those living with KOA.
Participants received a weekly dose of 50,000 IU of oral cholecalciferol (vitamin D3) for a span of two months. By the end of the treatment, nearly all participants had sufficient levels of vitamin D. Significant improvements were observed; serum vitamin D levels rose, quadriceps muscle strength increased, and knee pain decreased for the majority of participants.
Specifically, the pain reduction was measurable through standard pain assessment methods. The findings suggest a clear link between correcting vitamin D deficiency and improvements in both muscle strength and pain levels for those living with KOA.
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9
We examined the impact of vitamin D3 in a patient suffering from adult Fanconi syndrome, who experienced notable knee pain among other symptoms. This individual, a 42-year-old female, presented with various issues including progressive proximal muscle weakness and marked bone discomfort, particularly in the knees. After a thorough evaluation that included electromyography and a muscle biopsy, she was diagnosed with this rare condition, which often results in deficiencies that can lead to significant pain and discomfort.
Following a comprehensive treatment plan, which included tricalcium phosphate, vitamin D3, and sodium bicarbonate, we observed positive changes in her symptoms. The patient's knee pain, along with other discomforts, notably improved after a six-week supplementation regimen. However, it's essential to clarify that while vitamin D3 was part of a combined treatment, the specific contribution of vitamin D3 to alleviating knee pain is hard to isolate. We conclude that vitamin D3 may offer some benefits when included in a broader treatment framework, but further research would be needed to fully understand its role in managing knee pain specifically.
Following a comprehensive treatment plan, which included tricalcium phosphate, vitamin D3, and sodium bicarbonate, we observed positive changes in her symptoms. The patient's knee pain, along with other discomforts, notably improved after a six-week supplementation regimen. However, it's essential to clarify that while vitamin D3 was part of a combined treatment, the specific contribution of vitamin D3 to alleviating knee pain is hard to isolate. We conclude that vitamin D3 may offer some benefits when included in a broader treatment framework, but further research would be needed to fully understand its role in managing knee pain specifically.
Read More
8
We investigated the role of vitamin D3 in managing post-operative knee pain in patients undergoing unicompartmental knee arthroplasty (UKA). Our study involved 240 patients divided into three groups. One group received vitamin D3 supplements before surgery, another group received them afterward, and the last group had normal vitamin D levels from the start.
By examining bone pain levels at different intervals post-surgery, we could see how vitamin D3 supplementation could affect recovery. The results showed that correcting vitamin D deficiency before surgery led to significantly better pain control afterward. It highlighted the importance of checking vitamin D levels before undergoing knee surgery, as proper treatment can enhance patient outcomes dramatically.
Overall, our findings suggest that addressing vitamin D deficiency is a critical factor for a smoother post-surgery recovery process. It not only helps in reducing pain but also may contribute to better overall knee function after surgery.
By examining bone pain levels at different intervals post-surgery, we could see how vitamin D3 supplementation could affect recovery. The results showed that correcting vitamin D deficiency before surgery led to significantly better pain control afterward. It highlighted the importance of checking vitamin D levels before undergoing knee surgery, as proper treatment can enhance patient outcomes dramatically.
Overall, our findings suggest that addressing vitamin D deficiency is a critical factor for a smoother post-surgery recovery process. It not only helps in reducing pain but also may contribute to better overall knee function after surgery.
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User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced knee pain
The most important thing is that my joints have stopped crunching and they hurt less. After getting tested, I discovered there was no underlying issue for my sensations. Now, after nearly three months of taking the dietary supplement, I’m delighted to find that I hardly feel any pain. My shoulder still aches, but my knee pain and discomfort in my fingers have significantly decreased.
Read More
7.5
Less knee pain
One of the best! This vitamin D is ideal for the whole family. My children enjoy taking it, and so do the adults. We take it consistently from September to May, as it’s essential in St. Petersburg. The dosage is perfect for our region, and I’ve noticed that my pain, including knee pain, has significantly lessened. I highly recommend it!
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Montemor CN, Fernandes MTP, Marquez AS, Bignardi PR, Poli RC, et al. Impact of Reduced Vitamin D Levels on Pain, Function, and Severity in Knee or Hip Osteoarthritis. Nutrients. 2025;17. 10.3390/nu17030447
- Mende LK, Kuthati Y, Wong CS. Curcumin and Vitamin D Supplement Attenuates Knee Osteoarthritis Progression in ACLT + MMx Rat Model: Effect on Cartilage Protection and Pain Reduction. Nutrients. 2025;17. 10.3390/nu17020349
- Rajani AM, Mittal A, Kulkarni VU, Rajani KA, Rajani KA. Role of Pre-operative Correction of Vitamin D3 Deficiency in Controlling Post-operative Bone Pain after Unicompartmental Knee Arthroplasty. Malays Orthop J. 2024;18:7. 10.5704/MOJ.2411.002
- Gottreich JR, Katz JN, Jones MH. Nonsurgical Knee Osteoarthritis Treatments for Reducing Inflammation as Measured on MRI Scans: A Systematic Review of Randomized Controlled Trials. Orthop J Sports Med. 2024;12:23259671241272667. 10.1177/23259671241272667
- Zuo A, Jia Q, Zhang M, Zhou X, Li T, et al. The association of vitamin D with knee osteoarthritis pain: an analysis from the Osteoarthritis Initiative database. Sci Rep. 2024;14:30176. 10.1038/s41598-024-81845-6
- Wang QW, Ong MT, Man GC, Yeung YM, He X, et al. The effectiveness of vitamin D supplementation in patients with end-stage knee osteoarthritis: Study protocol for a double-blinded, randomized controlled trial. PLoS One. 2024;19:e0309610. 10.1371/journal.pone.0309610
- Saengsiwaritt W, Jittikoon J, Chaikledkaew U, Tawonsawatruk T, Honsawek S, et al. Effect of vitamin D supplementation on circulating level of autophagosome protein LC3A, inflammation, and physical performance in knee osteoarthritis. Clin Transl Sci. 2023;16:2543. 10.1111/cts.13646
- Wang Z, Zhu Z, Pan F, Zheng S, Parameswaran V, et al. Long-term effects of vitamin D supplementation and maintaining sufficient vitamin D on knee osteoarthritis over 5Â years. Arthritis Res Ther. 2023;25:178. 10.1186/s13075-023-03167-8
- Wang R, Wang ZM, Xiang SC, Jin ZK, Zhang JJ, et al. Relationship between 25-hydroxy vitamin D and knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. Front Med (Lausanne). 2023;10:1200592. 10.3389/fmed.2023.1200592
- Busa P, Huang N, Kuthati Y, Wong CS. Vitamin D reduces pain and cartilage destruction in knee osteoarthritis animals through inhibiting the matrix metalloprotease (MMPs) expression. Heliyon. 2023;9:e15268. 10.1016/j.heliyon.2023.e15268
- Shen J, Lin X, Lin Y, Xiao J, Wu C, et al. Supplementation of hyaluronic acid injections with vitamin D improve knee function by attenuating synovial fluid oxidative stress in osteoarthritis patients with vitamin D insufficiency. Front Nutr. 2023;10:1026722. 10.3389/fnut.2023.1026722
- Divjak A, Jovanovic I, Matic A, Lucic AT, Gajovic N, et al. The influence of vitamin D supplementation on the expression of mediators of inflammation in knee osteoarthritis. Immunol Res. 2023;71:442. 10.1007/s12026-022-09354-0
- Lin T, Peng S, Lu S, Fu S, Zeng D, et al. Prediction of knee pain improvement over two years for knee osteoarthritis using a dynamic nomogram based on MRI-derived radiomics: a proof-of-concept study. Osteoarthritis Cartilage. 2023;31:267. 10.1016/j.joca.2022.10.014
- Strath LJ, Hernandez PV, Nodarse CL, Johnson AJ, Edberg JD, et al. Clinical vitamin D levels are associated with insular volume and inferior temporal gyrus white matter surface area in community-dwelling individuals with knee pain. Front Neurosci. 2022;16:882322. 10.3389/fnins.2022.882322
- Jin X, Ding C, Hunter DJ, Gallego B. Effectiveness of vitamin D supplementation on knee osteoarthritis - A target trial emulation study using data from the Osteoarthritis Initiative cohort. Osteoarthritis Cartilage. 2022;30:1495. 10.1016/j.joca.2022.06.005
- Peng HM, Weng XS, Li Y, Feng B, Qian W, et al. Effect of alendronate sodium plus vitamin D tablets on knee joint structure and osteoarthritis pain: a multi-center, randomized, double-blind, placebo-controlled study protocol. BMC Musculoskelet Disord. 2022;23:584. 10.1186/s12891-022-05521-4
- Qi L, Guo Y. Fibrodysplasia Ossificans Progressiva: A Case Report. Cureus. 2024;16:e55528. 10.7759/cureus.55528
- Maniar RN, Maniar AR, Jain D, Bhatnagar N, Gajjar A. Vitamin D Trajectory after Total Knee Arthroplasty: A Method for Quick Correction in Deficient Patients. Clin Orthop Surg. 2021;13:336. 10.4055/cios20147
- Tu L, Zheng S, Cicuttini F, Jin X, Han W, et al. Effects of Vitamin D Supplementation on Disabling Foot Pain in Patients With Symptomatic Knee Osteoarthritis. Arthritis Care Res (Hoboken). 2021;73:781. 10.1002/acr.24371
- Gao XR, Chen YS, Deng W. The effect of vitamin D supplementation on knee osteoarthritis: A meta-analysis of randomized controlled trials. Int J Surg. 2017;46:14. 10.1016/j.ijsu.2017.08.010
- Xu C, Ma C, Bai Y. A pediatric hypophosphatemic rickets on MRI, Tc-MDP bone scan and F-FDG PET/CT. Hell J Nucl Med. 2017;20:93. 10.1967/s002449910515
- Jin X, Jones G, Cicuttini F, Wluka A, Zhu Z, et al. Effect of Vitamin D Supplementation on Tibial Cartilage Volume and Knee Pain Among Patients With Symptomatic Knee Osteoarthritis: A Randomized Clinical Trial. JAMA. 2016;315:1005. 10.1001/jama.2016.1961
- Heidari B, Javadian Y, Babaei M, Yousef-Ghahari B. Restorative Effect of Vitamin D Deficiency on Knee Pain and Quadriceps Muscle Strength in Knee Osteoarthritis. Acta Med Iran. 2015;53:466.
- McAlindon T, LaValley M, Schneider E, Nuite M, Lee JY, et al. Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial. JAMA. 2013;309:155. 10.1001/jama.2012.164487
- Cao Y, Jones G, Cicuttini F, Winzenberg T, Wluka A, et al. Vitamin D supplementation in the management of knee osteoarthritis: study protocol for a randomized controlled trial. Trials. 2012;13:131. 10.1186/1745-6215-13-131
- Lian LM, Chang YC, Yang CC, Yang JC, Kao KP, et al. Adult Fanconi syndrome with proximal muscle weakness and hypophosphatemic osteomalacia: report of a case. J Formos Med Assoc. 1994;93:709.
